Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
USERS' SCORE
Medium or Average
Based on 16 Reviews
6.8
Supplement Facts
Serving Size: 1 Veggie Capsule
Serving Per Container: 60
Amount Per Serving
%DV
Vitamin K2 (from MenaQ7® Menaquinone, MK-7)
45 mcg
38%
Top Medical Research Studies
9
We examined how Menaquinone-4, a form of vitamin K2, could help protect the heart during a critical event known as ischemia-reperfusion (I/R) injury, which often occurs after heart attacks. In our study, we used thirty-two rats, dividing them into three groups: a control group that experienced I/R without treatment, a group that received MK-4 before the injury, and another group that got MK-4 at the beginning of the recovery phase.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
Read More
8
We explored the effect of dietary intake of menaquinone, commonly known as vitamin K2, on heart attack risk and overall heart health. The investigation drew on data from the Rotterdam Study, tracking 4,807 individuals who did not have prior heart attacks.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Read More
7
We examined the effectiveness of rivaroxaban compared to vitamin K antagonists (VKAs) in treating patients with left ventricular thrombus (LVT) following a heart attack. Our retrospective study involved 1,335 patients and found that rivaroxaban not only worked as effectively as VKAs but also led to quicker LVT resolution.
Although patients taking rivaroxaban experienced fewer adverse events, the difference in bleeding risks between the two treatments wasn't significant. These findings suggest that rivaroxaban may offer clinical advantages, but further research is necessary to confirm these results.
Although patients taking rivaroxaban experienced fewer adverse events, the difference in bleeding risks between the two treatments wasn't significant. These findings suggest that rivaroxaban may offer clinical advantages, but further research is necessary to confirm these results.
Read More
Most Useful Reviews
0
Palpitations noted
20 people found this helpful
I experienced heart palpitations with this Vitamin K2 M7 variant, which frightened me to consider taking another capsule. I found MK4 to be much better, as I had no issues with palpitations. If you have a history of heart issues, I recommend avoiding this.
Read More
9
Blood pressure stabilization
14 people found this helpful
My husband started taking vitamin K2 with Grape Seed Extract. Since then, he's been able to stop taking his BP medication. This combination has stabilised his blood pressure and prevented panic attacks related to pharmaceuticals.
Read More
0
Raised heart rate
I tried MK7 for its longer duration but after taking just one pill, my heart rate rose from approximately 70 to nearly 100. On day three, my heart rate remains around 90. I will revert to MK4.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
- All Researches
9
Coumarin indicates potential heart protection
We investigated the cardioprotective effects of a newly developed coumarin, known as 5,6-PhSHC, on heart damage caused by isoproterenol-induced myocardial infarction in rats. The study involved treating rats with 5,6-PhSHC or clopidogrel before inducing a heart attack.
Our findings showed that 5,6-PhSHC improved electrocardiogram patterns and reduced markers of heart injury. Additionally, it helped reverse tissue damage and regulated cholesterol levels. While the results are promising, more research is needed to determine its potential for human use.
Our findings showed that 5,6-PhSHC improved electrocardiogram patterns and reduced markers of heart injury. Additionally, it helped reverse tissue damage and regulated cholesterol levels. While the results are promising, more research is needed to determine its potential for human use.
Read More
9
We examined how Menaquinone-4, a form of vitamin K2, could help protect the heart during a critical event known as ischemia-reperfusion (I/R) injury, which often occurs after heart attacks. In our study, we used thirty-two rats, dividing them into three groups: a control group that experienced I/R without treatment, a group that received MK-4 before the injury, and another group that got MK-4 at the beginning of the recovery phase.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
Read More
8
Comparative effectiveness of antithrombotic therapies
We evaluated the outcomes of patients with left ventricular thrombus (LVT) after a heart attack, focusing on dual antithrombotic therapy (DAT) versus triple antithrombotic therapy (TAT).
Analyzing a decade's worth of records from our hospital, we found that those on DAT had significantly fewer major complications after one year compared to those on TAT, particularly in terms of bleeding.
With over two-thirds of complications occurring shortly after discharge, the findings suggest that DAT may be the safer option for these patients. However, a randomized study is needed for confirmation.
Analyzing a decade's worth of records from our hospital, we found that those on DAT had significantly fewer major complications after one year compared to those on TAT, particularly in terms of bleeding.
With over two-thirds of complications occurring shortly after discharge, the findings suggest that DAT may be the safer option for these patients. However, a randomized study is needed for confirmation.
Read More
8
We examined whether novel oral anticoagulants (NOACs) are more effective than vitamin K antagonists (VKAs) for treating left ventricular thrombus in heart attack patients. In our observational study of 2328 patients, we found that 4.3% had left ventricular thrombus.
Those treated with NOACs showed faster and better thrombus resolution at one year compared to the VKA group. Additionally, major bleeding events were significantly lower in the NOAC group. These findings suggest that NOACs could offer a safer and more effective option for patients post-heart attack.
Those treated with NOACs showed faster and better thrombus resolution at one year compared to the VKA group. Additionally, major bleeding events were significantly lower in the NOAC group. These findings suggest that NOACs could offer a safer and more effective option for patients post-heart attack.
Read More
8
We explored the effect of dietary intake of menaquinone, commonly known as vitamin K2, on heart attack risk and overall heart health. The investigation drew on data from the Rotterdam Study, tracking 4,807 individuals who did not have prior heart attacks.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 16 Reviews
6.8
- All Reviews
- Positive Reviews
- Negative Reviews
0
Palpitations noted
20 people found this helpful
I experienced heart palpitations with this Vitamin K2 M7 variant, which frightened me to consider taking another capsule. I found MK4 to be much better, as I had no issues with palpitations. If you have a history of heart issues, I recommend avoiding this.
Read More
9
Blood pressure stabilization
14 people found this helpful
My husband started taking vitamin K2 with Grape Seed Extract. Since then, he's been able to stop taking his BP medication. This combination has stabilised his blood pressure and prevented panic attacks related to pharmaceuticals.
Read More
0
Raised heart rate
I tried MK7 for its longer duration but after taking just one pill, my heart rate rose from approximately 70 to nearly 100. On day three, my heart rate remains around 90. I will revert to MK4.
Read More
0
Not suitable for me
This could be a good product for those who do not experience side effects from K2 (MK-7). Unfortunately, I suffer from heart palpitations when using this supplement.
Read More
9
Vascular calcification prevention
6 people found this helpful
This form of vitamin K2 is excellent for preventing vascular calcification. I recommend pairing it with high doses of vitamin D3. I prefer to take them separately, and this combination works perfectly for me. I wholeheartedly advise you to try this.
Read More
Frequently Asked Questions
9
Blood pressure stabilization
14 people found this helpful
My husband started taking vitamin K2 with Grape Seed Extract. Since then, he's been able to stop taking his BP medication. This combination has stabilised his blood pressure and prevented panic attacks related to pharmaceuticals.
0
Palpitations noted
20 people found this helpful
I experienced heart palpitations with this Vitamin K2 M7 variant, which frightened me to consider taking another capsule. I found MK4 to be much better, as I had no issues with palpitations. If you have a history of heart issues, I recommend avoiding this.
7.5
Good for absorption
I take vitamin K2 with D3 for better calcium absorption and to prevent vascular calcification. It has a good composition that benefits the heart and blood vessels and even improves skin condition. My parents also take it and respond well.
9
Vascular calcification prevention
6 people found this helpful
This form of vitamin K2 is excellent for preventing vascular calcification. I recommend pairing it with high doses of vitamin D3. I prefer to take them separately, and this combination works perfectly for me. I wholeheartedly advise you to try this.
7.5
Survival extension
1 people found this helpful
Taking vitamin K2 appears to lower the risk of dying from coronary heart disease and reduces arterial calcification. Many people lack this vitamin over time, making supplementation vital for heart health and bone strength.
0
Not suitable for me
This could be a good product for those who do not experience side effects from K2 (MK-7). Unfortunately, I suffer from heart palpitations when using this supplement.
0
Raised heart rate
I tried MK7 for its longer duration but after taking just one pill, my heart rate rose from approximately 70 to nearly 100. On day three, my heart rate remains around 90. I will revert to MK4.
9
Heart attack prevention
4 people found this helpful
Vitamin K2 is crucial for preventing calcium build-up in the arteries, taking calcium to the bones, and reducing the risk of heart attack. Consult your doctor and take care of your health.
5
Cardiovascular health
8 people found this helpful
Vitamin K2 (menaquinone) is a fat-soluble vitamin vital for blood clotting and preventing calcium accumulation in blood vessels. It enhances calcium absorption, supports cardiovascular health, and may reduce the risk of heart attack, diabetes, and osteoporosis. This nutrient also contributes to youthful skin and better digestion.
8
We explored the effect of dietary intake of menaquinone, commonly known as vitamin K2, on heart attack risk and overall heart health. The investigation drew on data from the Rotterdam Study, tracking 4,807 individuals who did not have prior heart attacks.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
Through careful analysis, we observed a noteworthy finding: people who consumed higher amounts of menaquinone had a significantly reduced risk of coronary heart disease (CHD) and all-cause mortality. Specifically, those in the mid to upper intake levels of menaquinone exhibited a risk reduction of 27% and 57% for heart-related deaths compared to those with lower intake.
Interestingly, we found that menaquinone intake also seemed to correlate with lower instances of severe aortic calcification, suggesting its potential role in preventing vascular issues. On the other hand, our analysis indicated that phylloquinone, or vitamin K1, did not show any significant relationship with these health outcomes.
These findings underscore the importance of adequate menaquinone consumption as a potential strategy for heart attack prevention and cardiovascular health improvement.
9
We examined how Menaquinone-4, a form of vitamin K2, could help protect the heart during a critical event known as ischemia-reperfusion (I/R) injury, which often occurs after heart attacks. In our study, we used thirty-two rats, dividing them into three groups: a control group that experienced I/R without treatment, a group that received MK-4 before the injury, and another group that got MK-4 at the beginning of the recovery phase.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
By using a specialized apparatus to assess heart function, we measured various indicators of heart health, including the pressure the heart could generate and rates of heart contractions. We also examined markers of heart damage and stress, like enzymes and inflammatory signals.
Our findings were promising. The group that received MK-4 after the I/R injury showed a significant reduction in the size of heart damage, alongside improved heart function. This group also had lower levels of markers related to heart stress and damage, indicating that MK-4 might help the heart recover from the stress of a heart attack. Overall, these results suggest that vitamin K2 could be a valuable ally in enhancing heart health during recovery from ischemic events.
9
Coumarin indicates potential heart protection
We investigated the cardioprotective effects of a newly developed coumarin, known as 5,6-PhSHC, on heart damage caused by isoproterenol-induced myocardial infarction in rats. The study involved treating rats with 5,6-PhSHC or clopidogrel before inducing a heart attack.
Our findings showed that 5,6-PhSHC improved electrocardiogram patterns and reduced markers of heart injury. Additionally, it helped reverse tissue damage and regulated cholesterol levels. While the results are promising, more research is needed to determine its potential for human use.
Our findings showed that 5,6-PhSHC improved electrocardiogram patterns and reduced markers of heart injury. Additionally, it helped reverse tissue damage and regulated cholesterol levels. While the results are promising, more research is needed to determine its potential for human use.
References
- Ghazouani L, Khdhiri E, Elmufti A, Zarei A, Feriani A, et al. A novel synthetised sulphonylhydrazone coumarin (E)-4-methyl-N'-(1-(3-oxo-3H-benzo[f]chromen-2- yl)ethylidene)benzenesulphonohydrazide protect against isoproterenol-induced myocardial infarction in rats by attenuating oxidative damage, biological changes and electrocardiogram. Clin Exp Pharmacol Physiol. 2022;49:1010. doi:10.1111/1440-1681.13690
- Park J, Jung JH, Choi EK, Lee SW, Kwon S, et al. Comparison of early clinical outcomes between dual antiplatelet therapy and triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention. PLoS One. 2022;17:e0264538. doi:10.1371/journal.pone.0264538
- De Luca L, Putini RL, Natale E, Terranova A, Piazza V, et al. One-year clinical outcome of patients with left ventricular thrombus after acute myocardial infarction discharged on triple or dual antithrombotic therapy. J Thromb Thrombolysis. 2022;53:410. doi:10.1007/s11239-021-02577-2
- Zhang Z, Si D, Zhang Q, Qu M, Yu M, et al. Rivaroxaban versus Vitamin K Antagonists (warfarin) based on the triple therapy for left ventricular thrombus after ST-Elevation myocardial infarction. Heart Vessels. 2022;37:374. doi:10.1007/s00380-021-01921-z
- Alcalai R, Butnaru A, Moravsky G, Yagel O, Rashad R, et al. Apixaban vs. warfarin in patients with left ventricular thrombus: a prospective multicentre randomized clinical trial‡. Eur Heart J Cardiovasc Pharmacother. 2022;8:660. doi:10.1093/ehjcvp/pvab057
- Wang MT, Hung CC, Lin KC, Mar GY, Kuo SH, et al. Comparison of effects of triple antithrombotic therapy and dual antiplatelet therapy on long-term outcomes of acute myocardial infarction. Heart Vessels. 2021;36:345. doi:10.1007/s00380-020-01708-8
- Jones DA, Wright P, Alizadeh MA, Fhadil S, Rathod KS, et al. The use of novel oral anticoagulants compared to vitamin K antagonists (warfarin) in patients with left ventricular thrombus after acute myocardial infarction. Eur Heart J Cardiovasc Pharmacother. 2021;7:398. doi:10.1093/ehjcvp/pvaa096
- Hassan AE, Hadhoud S, Elmahdi E, Elkattawy HA. Potential Cardioprotective Role of Menaquinone-4 Against Cardiac Ischemia-reperfusion Injury. J Cardiovasc Pharmacol. 2023;81:381. doi:10.1097/FJC.0000000000001413
- Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004;134:3100.
